Shytaj Lab

Exploring viral-host metabolism for therapeutic innovation

About the Lab

We are an international research group at the University of Bristol, United Kingdom, studying how intracellular metabolic dysregulation influences viral replication and persistence, with a particular focus on the human retroviruses HIV‑1 and HTLV‑1.

Our work integrates multi‑omics analyses with primary cell models and patient‑derived samples, and through close collaboration with clinical partners in the UK and abroad, we aim to link molecular discoveries and therapeutic development to deliver tangible real‑world benefits.

Our Team

Iart Luca Shytaj

Iart Luca Shytaj

Group Leader

Luca obtained his PhD in 2014 in Infectious Diseases working at the Italian National Institute of Health in Rome, Italy. His PhD work led to the development of a macaque model for studying the persistence of simian immunodeficiency virus during antiretroviral therapy. During his postdoctoral research at Heidelberg University Hospital in Germany, he explored how redox balance and glycolytic metabolism influence the establishment and maintenance of HIV latency. Several of the therapeutic strategies he tested advanced to a clinical trial in São Paulo, Brazil, where he later served as a Visiting Professor between 2020–2022. In 2022, he established his independent research group at the University of Bristol, becoming Senior Lecturer in 2024.

Lara Gallucci

Lara Gallucci

Marie Curie Research Fellow

Lara obtained her PhD at the University of Bordeaux (Bordeaux, France), where she studied the nuclear import of the Hepatitis B virus. She then moved to the Center for Integrative Infectious Disease Research in Heidelberg (Germany) as a postdoctoral researcher, focusing on the role of the 3D environment during HIV‑1 infection. She is currently a Marie Curie Research Fellow, where her research focuses on metabolic dysregulation induced by retroviruses such as HIV‑1 and HTLV‑1 in primary and patient‑derived cells.

Dr. Vincent Cantaloube‑Ferrieu

Vincent Cantaloube‑Ferrieu

Postdoctoral Fellow

Vincent obtained his PhD at the University of Toulouse (France), where he studied HIV‑1 infection of macrophages via cell‑to‑cell fusion with infected CD4+ T lymphocytes. He joined the lab in August 2024 as a postdoctoral fellow and is currently working on identifying molecular signatures that distinguish latently infected cells from uninfected or actively infected ones — with a particular focus on metabolic discrepancies during HIV‑1 latency.

Phoebe Kibble

Phoebe Kibble

PhD Student

Phoebe is a PhD student investigating HIV‑1 infection mechanics with a focus on latency and active replication using proteomic and pharmacological approaches. She earned an Integrated Master’s degree in Biomedical Sciences with Honours from Cardiff University in 2023. Her prior work includes research on Escherichia coli, Neisseria meningitidis, SARS‑CoV‑2, and other pathogens.

Harsha Mambully

Harsha Mambully

Visiting PhD Student

Harsha is a Commonwealth Split-Site visiting PhD student from Prof. Amit Singh’s laboratory at the Indian Institute of Science (IISc), Bangalore, India. She earned a BS–MS Dual Degree in Biological Sciences from the Indian Institute of Science Education and Research (IISER), Bhopal, India. Harsha studies HIV-1 antioxidant metabolism in the context of HIV latency and has prior experience in HIV-1 latency models, nanozymes, and Drosophila neurogenetics.

Maria Josephine

Maria Josephine

Research Technician

Josephine holds a BSc in Biomedical Sciences from Newcastle University, where she focused her dissertation on Flt3‑ligand regulation in paediatric AML. She previously worked at AstraZeneca (Cambridge) on lead optimisation of an alpha‑helical peptide using machine learning and phage display, and held assistant positions in the Amarnath Immune Regulation Group and the Newcastle Brain Tissue Resource.

Elizabeth Hanna

Elizabeth Hanna

Master of Research

Elizabeth completed her medical degree at the University of Cambridge in 2023 and then worked as a resident doctor in NHS Grampian for the following two years. Her area of research is investigating metabolic changes which occur in lymphoid organoids latently infected with HIV.

Trusha Ramteke

Trusha Ramteke

Master of Research

Trusha completed her bachelor’s degree in Biology and undertook internships at the National University of Singapore and the University of Cambridge. Her past work spans bacterial biofilms, the murine epididymis, and cellular autophagy. During her MRes, she will use CRISPR-Cas to investigate the determinants of mitochondrial dysregulation in HTLV-1–infected cells.

Beth Hoare

Beth Hoare

MSci

Beth is completing her MSci in Virology and Immunology. For her dissertation, she is screening candidate therapeutics aimed at the selective elimination of HTLV-1–infected adult T-cell leukaemia cells.

Rebecca Lin

Rebecca Lin

MSci

Rebecca is completing her MSci in Virology and Immunology. For her dissertation, she is screening candidate therapeutics aimed at the selective elimination of HTLV-1–infected adult T-cell leukaemia cells.

Alumni

  • Sophie Shackley – MSci Student (2024–2025)
  • Alex Quin – MSci Student (2024–2025)
  • Cristian Voiculescu – MSci Student (2023–2024)
  • Millie Robinson – MSci Student (2022–2023)

Research

All Publications

For a full list of publications, see:

Other Outputs

For a list of patents and patent applications, see:

Join the Lab

We welcome expressions of interest from motivated students and postdoctoral researchers. The lab can also support applications from suitable candidates to several internationally competitive fellowship programmes, including:

Funded opportunities to join the lab will appear below when available. If you are interested in joining through external funding or personal fellowships, please contact the PI at luca.shytaj@bristol.ac.uk.

News & Highlights

2025

Lab Visit to São Caetano do Sul Covered in Brazilian Media

Our recent exchange visit to the University of São Caetano do Sul was featured by multiple Brazilian news outlets.

USCS Official Release · ABC do ABC · Repórter Diário

Anti‑HIV / Anti‑Cancer Therapy Featured on Advanced Science Inside Cover

Our research on a dual‑function molecule with antiviral and anti‑leukemic activity was featured on the inside cover of Advanced Science.

View the publication

Presentation at BIOVARIA 2025 (Munich)

Luca presented the results on broad-spectrum anti-coronavirus agents and the related patent at BIOVARIA 2025 in Munich.

View the conference programme

2023

MSci Student Millie Robinson Awarded Lucy Brown Cancer Prize

Our MSci student, Millie Robinson, received the Lucy Brown Cancer Prize for her thesis research on a compound with promising dual anti‑cancer and anti‑HIV activity.

Read more on the University of Bristol website

HIV Drug Investigated for Broad‑Spectrum Coronavirus Inhibition

Our study on repurposing HIV therapeutics to block human coronavirus replication was featured in University and other news outlets.

University of Bristol News · EATG

Lab Photos

Click the title to open the gallery.

Lab Photos

Contact

Shytaj Lab

Biomedical Sciences Building

School of Biochemistry and Cellular and Molecular Medicine

University of Bristol

BS8 1TD, Bristol, United Kingdom

Email: luca.shytaj@bristol.ac.uk